:root {
    /* ── Palette Clean Clinical (Vert & Blanc) ── */
    --primary-green:         #0f766e; /* Teal 700 - Vert médical de confiance */
    --primary-green-hover:   #115e59; /* Teal 800 */
    --primary-green-light:   #f0fdfa; /* Teal 50 - Fond clair doux */
    --primary-green-border:  #ccfbf1; /* Teal 100 - Bordures douces */
    --accent-green:          #0d9488; /* Teal 600 - Accentuation */
    
    --success-green:         #16a34a; /* Green 600 - Succès/Actif */
    --success-bg:            #f0fdf4; /* Green 50 */
    --success-border:        #bbf7d0; /* Green 200 */
    
    --warning-text:          #b45309; /* Amber 700 - Avertissement */
    --warning-bg:            #fffbeb; /* Amber 50 */
    --warning-border:        #fde68a; /* Amber 200 */

    --bg-base:               #f8fafc; /* Slate 50 - Fond d'application clean */
    --bg-card:               #ffffff; /* Blanc pur pour les cartes */
    --border-color:          #e2e8f0; /* Slate 200 */

    --text-primary:          #0f172a; /* Slate 900 */
    --text-secondary:        #475569; /* Slate 600 */
    --text-muted:            #64748b; /* Slate 500 */

    --border-radius:         12px;
    --border-radius-sm:      8px;
    
    /* ── Transitions & Ombres ── */
    --transition-fast:       150ms cubic-bezier(0.4, 0, 0.2, 1);
    --transition-base:       250ms cubic-bezier(0.4, 0, 0.2, 1);
    --transition-slow:       350ms cubic-bezier(0.4, 0, 0.2, 1);
    
    --shadow-sm:             0 1px 2px 0 rgba(15, 23, 42, 0.05);
    --shadow-md:             0 4px 6px -1px rgba(15, 23, 42, 0.05), 0 2px 4px -2px rgba(15, 23, 42, 0.05);
    --shadow-lg:             0 10px 15px -3px rgba(15, 23, 42, 0.04), 0 4px 6px -4px rgba(15, 23, 42, 0.04);
}

* {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

body {
    font-family: 'Inter', sans-serif;
    background-color: var(--bg-base);
    background-image: 
        radial-gradient(at 0% 0%, rgba(204, 251, 241, 0.4) 0px, transparent 50%),
        radial-gradient(at 100% 100%, rgba(240, 253, 244, 0.6) 0px, transparent 50%);
    background-attachment: fixed;
    color: var(--text-primary);
    min-height: 100vh;
    line-height: 1.6;
    position: relative;
    overflow-x: hidden;
}

/* Layout */
.app-container {
    max-width: 1000px;
    margin: 0 auto;
    padding: 2rem 1.5rem;
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
    animation: fadeIn 0.4s ease-out;
}

.app-header {
    text-align: center;
    margin-bottom: 0.5rem;
}

.logo {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 0.6rem;
    color: var(--primary-green);
    margin-bottom: 0.25rem;
}

.logo svg {
    stroke: var(--primary-green);
    animation: pulseLogo 3s infinite ease-in-out;
}

.logo h1 {
    font-size: 1.8rem;
    font-weight: 700;
    letter-spacing: -0.5px;
}

.subtitle {
    color: var(--text-secondary);
    font-size: 0.9rem;
    font-weight: 400;
}

/* Glass Panels / Cards */
.glass-panel {
    background: var(--bg-card);
    border: 1px solid var(--border-color);
    border-radius: var(--border-radius);
    padding: 1.5rem 1.75rem;
    box-shadow: var(--shadow-lg);
    transition: box-shadow var(--transition-base), transform var(--transition-base);
}

.glass-panel:hover {
    box-shadow: 0 12px 20px -3px rgba(15, 23, 42, 0.06), 0 4px 8px -4px rgba(15, 23, 42, 0.06);
}

.glass-panel h2 {
    margin-bottom: 1.25rem;
    font-size: 0.85rem;
    font-weight: 700;
    letter-spacing: 0.08em;
    text-transform: uppercase;
    color: var(--primary-green);
    border-bottom: 2px solid var(--primary-green-border);
    padding-bottom: 0.5rem;
    display: inline-block;
}

/* Calculator Grid */
.calc-grid {
    display: grid;
    grid-template-columns: 1fr auto 40%;
    gap: 2rem;
    align-items: start;
    margin-bottom: 1.5rem;
}

.calc-card {
    background: transparent;
    border: none;
    padding: 0;
}

.card-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 1rem;
}

.card-header h3 {
    font-size: 0.8rem;
    font-weight: 700;
    letter-spacing: 0.06em;
    text-transform: uppercase;
    color: var(--text-secondary);
    margin: 0;
}

/* Buttons */
.btn-small {
    background: var(--primary-green-light);
    color: var(--primary-green);
    border: 1px solid var(--primary-green-border);
    padding: 0.45rem 0.9rem;
    border-radius: var(--border-radius-sm);
    font-weight: 600;
    cursor: pointer;
    font-size: 0.8rem;
    display: inline-flex;
    align-items: center;
    gap: 0.3rem;
    transition: all var(--transition-fast);
}

.btn-small:hover {
    background: var(--primary-green);
    color: white;
    transform: translateY(-1px);
    box-shadow: var(--shadow-sm);
}

.btn-small:active {
    transform: translateY(0);
}

.conversion-arrow {
    display: flex;
    align-items: center;
    justify-content: center;
    color: var(--primary-green);
    align-self: center;
    height: 100%;
}

.conversion-arrow svg {
    stroke-width: 2.5;
    animation: bounceRight 2s infinite alternate ease-in-out;
}

/* Inputs and Forms */
.form-group {
    margin-bottom: 0.85rem;
}

label {
    display: block;
    margin-bottom: 0.35rem;
    font-size: 0.8rem;
    font-weight: 600;
    color: var(--text-secondary);
}

select, input {
    width: 100%;
    background: #ffffff;
    border: 1px solid var(--border-color);
    color: var(--text-primary);
    padding: 0.6rem 0.85rem;
    border-radius: var(--border-radius-sm);
    font-family: 'Inter', sans-serif;
    font-size: 0.9rem;
    outline: none;
    box-shadow: var(--shadow-sm);
    transition: all var(--transition-fast);
}

select:focus, input:focus {
    border-color: var(--primary-green);
    box-shadow: 0 0 0 3px rgba(15, 118, 110, 0.15);
}

.input-wrapper {
    position: relative;
    display: flex;
    align-items: center;
}

.input-wrapper .unit {
    position: absolute;
    right: 0.85rem;
    color: var(--text-muted);
    font-size: 0.8rem;
    font-weight: 500;
    pointer-events: none;
}

/* Source Rows (Multi) */
.source-row {
    display: flex;
    flex-wrap: wrap;
    gap: 0.75rem;
    align-items: flex-end;
    padding: 0.75rem;
    background: var(--bg-base);
    border-radius: var(--border-radius-sm);
    margin-bottom: 0.75rem;
    border: 1px solid var(--border-color);
    animation: slideIn 0.3s cubic-bezier(0.16, 1, 0.3, 1);
}

.source-row .form-group {
    margin-bottom: 0;
    flex: 1.5;
    min-width: 160px;
}

.source-row .dose-group {
    flex: 1;
    min-width: 100px;
}

.btn-remove {
    background: #fef2f2;
    color: #ef4444;
    border: 1px solid #fee2e2;
    width: 38px;
    height: 38px;
    border-radius: var(--border-radius-sm);
    cursor: pointer;
    transition: all var(--transition-fast);
    display: flex;
    align-items: center;
    justify-content: center;
}

.btn-remove:hover {
    background: #ef4444;
    color: white;
    border-color: #ef4444;
    transform: scale(1.05);
}

.btn-remove:active {
    transform: scale(0.95);
}

.btn-remove svg {
    width: 16px;
    height: 16px;
}

/* PRN Box */
.prn-usage-box {
    margin-top: 1rem;
    padding: 1rem;
    background: var(--primary-green-light);
    border-radius: var(--border-radius-sm);
    border: 1px dashed var(--primary-green-border);
}

.prn-usage-box h4 {
    font-size: 0.75rem;
    color: var(--primary-green);
    margin-bottom: 0.65rem;
    text-transform: uppercase;
    letter-spacing: 0.06em;
    font-weight: 700;
}

.prn-inputs {
    display: flex;
    gap: 0.75rem;
}

.prn-inputs .form-group {
    flex: 1;
    margin-bottom: 0;
}

.total-mme-display {
    margin-top: 1rem;
    padding-top: 0.75rem;
    border-top: 1px solid var(--border-color);
    font-size: 0.85rem;
    font-weight: 500;
    color: var(--text-secondary);
    text-align: right;
}

.total-mme-display span {
    font-size: 1.25rem;
    font-weight: 700;
    color: var(--primary-green);
    margin-left: 0.3rem;
}

/* Target Area Result */
.target-card h3 {
    font-size: 0.8rem;
    font-weight: 700;
    letter-spacing: 0.06em;
    text-transform: uppercase;
    color: var(--text-secondary);
    margin-bottom: 1rem;
}

.result-display {
    margin-top: 1.25rem;
    padding: 1.25rem;
    background: var(--bg-base);
    border-radius: var(--border-radius);
    border: 1px solid var(--border-color);
    text-align: center;
    transition: all var(--transition-base);
}

.result-display.has-value {
    background: var(--success-bg);
    border-color: var(--success-border);
    box-shadow: 0 0 15px rgba(22, 163, 74, 0.06);
    animation: pulseValue 0.4s ease-out;
}

.result-label {
    font-size: 0.85rem;
    color: var(--text-secondary);
    margin-bottom: 0.4rem;
    font-weight: 500;
}

.result-value {
    display: flex;
    align-items: baseline;
    justify-content: center;
}

.result-value span:first-child {
    font-size: 2.75rem;
    font-weight: 800;
    color: var(--text-primary);
    transition: color var(--transition-base);
}

.result-display.has-value .result-value span:first-child {
    color: var(--success-green);
}

.result-value .unit {
    font-size: 1.1rem;
    margin-left: 0.4rem;
    font-weight: 600;
    color: var(--text-secondary);
}

/* Warnings */
.warning-collapsible {
    margin-top: 1rem;
}

.warning-trigger {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 0.4rem;
    background: none;
    border: none;
    cursor: pointer;
    color: var(--text-secondary);
    font-size: 0.8rem;
    font-weight: 500;
    padding: 0.35rem 0;
    width: 100%;
}

.warning-icon {
    color: var(--primary-green);
}

.warning-chevron {
    width: 14px;
    height: 14px;
    transition: transform var(--transition-fast);
    flex-shrink: 0;
}

.warning-trigger[aria-expanded="true"] .warning-chevron {
    transform: rotate(180deg);
}

.warning-content {
    display: grid;
    grid-template-rows: 0fr;
    transition: grid-template-rows var(--transition-base);
}

.warning-content.is-open {
    grid-template-rows: 1fr;
}

.warning-content-inner {
    overflow: hidden;
}

.warning-content-body {
    margin-top: 0.5rem;
    font-size: 0.8rem;
    color: var(--warning-text);
    background: var(--warning-bg);
    border: 1px solid var(--warning-border);
    padding: 0.75rem 1rem;
    border-radius: var(--border-radius-sm);
    text-align: left;
}

/* Breakthrough Dose */
.breakthrough-dose {
    background: var(--bg-base);
    border: 1px solid var(--border-color);
    border-radius: var(--border-radius-sm);
    padding: 1rem 1.25rem;
    display: flex;
    gap: 1rem;
    align-items: flex-start;
    transition: all var(--transition-base);
}

.btd-icon {
    color: var(--primary-green);
    flex-shrink: 0;
    margin-top: 0.1rem;
}

.btd-content h4 {
    font-size: 0.75rem;
    font-weight: 700;
    letter-spacing: 0.06em;
    text-transform: uppercase;
    color: var(--text-secondary);
    margin-bottom: 0.25rem;
}

.btd-content p {
    font-size: 1.2rem;
    font-weight: 700;
    color: var(--primary-green);
    margin-bottom: 0.25rem;
}

.btd-content small {
    color: var(--text-secondary);
    font-size: 0.8rem;
    display: block;
    line-height: 1.4;
}

.btd-warning-text {
    display: block;
    margin-top: 0.5rem;
    padding: 0.4rem 0.6rem;
    color: var(--warning-text);
    background: var(--warning-bg);
    border-left: 3px solid var(--warning-text);
    border-radius: 0 var(--border-radius-sm) var(--border-radius-sm) 0;
    font-size: 0.78rem;
    font-weight: 500;
}

/* Justification Box */
.justification-box {
    display: none;
    margin-top: 1rem;
    background: var(--bg-base);
    border-radius: var(--border-radius-sm);
    padding: 1rem 1.25rem;
    border: 1px solid var(--border-color);
    animation: fadeIn 0.3s ease-out;
}

.justification-box h4 {
    font-size: 0.75rem;
    font-weight: 700;
    letter-spacing: 0.06em;
    text-transform: uppercase;
    color: var(--text-secondary);
    margin-bottom: 0.5rem;
}

.justification-list {
    color: var(--text-secondary);
    font-size: 0.82rem;
    margin-left: 1rem;
    line-height: 1.6;
}

.justification-list li {
    margin-bottom: 0.25rem;
}

.justification-list li span[style*="color:var(--warning-text)"] {
    display: inline-block;
    padding: 0.25rem 0.5rem;
    background: var(--warning-bg);
    border: 1px solid var(--warning-border);
    border-radius: 4px;
    margin-top: 0.25rem;
}

/* References Section */
.reference-section {
    margin-top: 0.5rem;
}

.reference-section .section-toggle {
    display: flex;
    align-items: center;
    justify-content: space-between;
    width: 100%;
    background: none;
    border: none;
    cursor: pointer;
    color: var(--primary-green);
    font-size: 0.8rem;
    font-weight: 700;
    letter-spacing: 0.06em;
    text-transform: uppercase;
    font-family: 'Inter', sans-serif;
    padding: 0.25rem 0;
    text-align: left;
}

.section-toggle-chevron {
    width: 16px;
    height: 16px;
    transition: transform var(--transition-fast);
    flex-shrink: 0;
}

.section-toggle[aria-expanded="true"] .section-toggle-chevron {
    transform: rotate(180deg);
}

.reference-section-content {
    display: grid;
    grid-template-rows: 0fr;
    transition: grid-template-rows var(--transition-base);
}

.reference-section-content.is-open {
    grid-template-rows: 1fr;
}

.reference-section-content-inner {
    overflow: hidden;
}

.table-filter-bar {
    margin-top: 1.25rem;
    margin-bottom: 1rem;
}

.filter-input-wrapper {
    position: relative;
    max-width: 320px;
}

.filter-input-wrapper svg.filter-icon {
    position: absolute;
    left: 0.75rem;
    top: 50%;
    transform: translateY(-50%);
    color: var(--text-muted);
    pointer-events: none;
    width: 16px;
    height: 16px;
}

#table-filter {
    padding-left: 2.25rem;
    padding-right: 2.25rem;
}

.filter-clear-btn {
    position: absolute;
    right: 0.6rem;
    top: 50%;
    transform: translateY(-50%);
    background: none;
    border: none;
    color: var(--text-muted);
    cursor: pointer;
    font-size: 1.2rem;
    line-height: 1;
    padding: 0.25rem;
    transition: color var(--transition-fast);
}

.filter-clear-btn:hover {
    color: var(--text-primary);
}

.filter-count {
    font-size: 0.75rem;
    color: var(--text-muted);
    margin-top: 0.35rem;
}

/* Tables */
.table-responsive {
    overflow-x: auto;
    border: 1px solid var(--border-color);
    border-radius: var(--border-radius-sm);
    margin-bottom: 1.25rem;
    box-shadow: var(--shadow-sm);
}

table {
    width: 100%;
    border-collapse: separate;
    border-spacing: 0;
    background: #ffffff;
}

th, td {
    padding: 0.85rem 1rem;
    text-align: left;
    border-bottom: 1px solid var(--border-color);
    font-size: 0.85rem;
}

th {
    background: var(--primary-green-light);
    color: var(--primary-green);
    font-weight: 700;
    white-space: nowrap;
    text-transform: uppercase;
    font-size: 0.75rem;
    letter-spacing: 0.05em;
}

tr:last-child td {
    border-bottom: none;
}

tr:hover td {
    background: #fafaf9;
}

.disclaimer {
    font-size: 0.8rem;
    color: var(--text-secondary);
    padding-top: 0.75rem;
    border-top: 1px solid var(--border-color);
    line-height: 1.5;
}

/* Print/Download Button Area */
.print-actions {
    margin-top: 1.5rem;
    text-align: center;
}

.btn-print {
    background: var(--primary-green);
    color: white;
    border: none;
    padding: 0.75rem 1.75rem;
    border-radius: var(--border-radius);
    font-weight: 700;
    cursor: pointer;
    font-size: 0.95rem;
    display: inline-flex;
    align-items: center;
    gap: 0.5rem;
    box-shadow: var(--shadow-md);
    transition: all var(--transition-base);
}

.btn-print:hover {
    background: var(--primary-green-hover);
    transform: translateY(-1.5px);
    box-shadow: 0 6px 12px -2px rgba(15, 118, 110, 0.25);
}

.btn-print:active {
    transform: translateY(0);
}

.btn-print:disabled {
    opacity: 0.65;
    cursor: not-allowed;
    transform: none !important;
    box-shadow: none !important;
}

/* Sticky Mobile Bar */
#sticky-result-bar {
    display: none;
    position: sticky;
    top: 0;
    z-index: 100;
    height: 54px;
    background: rgba(255, 255, 255, 0.95);
    backdrop-filter: blur(8px);
    -webkit-backdrop-filter: blur(8px);
    border-bottom: 1px solid var(--border-color);
    align-items: center;
    justify-content: space-between;
    padding: 0 1.25rem;
    opacity: 0;
    pointer-events: none;
    box-shadow: 0 2px 8px rgba(0,0,0,0.04);
    transition: opacity var(--transition-base);
}

#sticky-result-bar.is-visible {
    opacity: 1;
    pointer-events: auto;
}

.sticky-item {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--text-secondary);
}

.sticky-item strong {
    color: var(--primary-green);
    font-weight: 700;
}

/* Animations Definitions */
@keyframes fadeIn {
    from { opacity: 0; }
    to { opacity: 1; }
}

@keyframes slideIn {
    from { opacity: 0; transform: translateY(-8px); }
    to { opacity: 1; transform: translateY(0); }
}

@keyframes pulseLogo {
    0%, 100% { transform: scale(1); }
    50% { transform: scale(1.08); }
}

@keyframes bounceRight {
    0% { transform: translateX(0); }
    100% { transform: translateX(6px); }
}

@keyframes pulseValue {
    0% { transform: scale(1); }
    50% { transform: scale(1.03); }
    100% { transform: scale(1); }
}

/* Reduced Motion preferences */
@media (prefers-reduced-motion: reduce) {
    *, *::before, *::after {
        animation-duration: 0.01ms !important;
        animation-iteration-count: 1 !important;
        transition-duration: 0.01ms !important;
        scroll-behavior: auto !important;
    }
    .logo svg, .conversion-arrow svg {
        animation: none !important;
    }
}

/* Responsiveness */
@media (max-width: 900px) {
    .calc-grid {
        grid-template-columns: 1fr;
        gap: 1.25rem;
    }
    .conversion-arrow {
        transform: rotate(90deg);
        padding: 0.25rem 0;
        height: auto;
    }
    .conversion-arrow svg {
        animation: bounceDown 2s infinite alternate ease-in-out;
    }
    @keyframes bounceDown {
        0% { transform: translateY(0); }
        100% { transform: translateY(6px); }
    }
    #sticky-result-bar {
        display: flex;
    }
}

@media (max-width: 600px) {
    .app-container {
        padding: 1rem;
        gap: 1rem;
    }
    .glass-panel {
        padding: 1.25rem 1rem;
    }
    .source-row {
        flex-direction: column;
        align-items: stretch;
        gap: 0.5rem;
    }
    .source-row .form-group, .source-row .dose-group {
        flex: auto;
        width: 100%;
    }
    .btn-remove {
        width: 100%;
        margin-top: 0.25rem;
    }
    .prn-inputs {
        flex-direction: column;
        gap: 0.6rem;
    }
    .filter-input-wrapper {
        max-width: 100%;
    }
}

/* ── PDF RENDER SPECIFIC STYLES ── */
.pdf-rendering {
    background: #ffffff !important;
    box-shadow: none !important;
    border: none !important;
    padding: 0 !important;
    color: #000000 !important;
}

.pdf-rendering h2 {
    border-bottom: 2px solid #0f766e !important;
    color: #0f766e !important;
}

.pdf-rendering .btn-small,
.pdf-rendering .btn-remove,
.pdf-rendering .print-actions,
.pdf-rendering .warning-collapsible {
    display: none !important;
}

.pdf-rendering select {
    border: none !important;
    background: transparent !important;
    appearance: none !important;
    -webkit-appearance: none !important;
    font-weight: 700 !important;
    color: #000000 !important;
    padding-left: 0 !important;
    box-shadow: none !important;
}

.pdf-rendering input {
    border: none !important;
    background: transparent !important;
    font-weight: 700 !important;
    color: #000000 !important;
    padding-left: 0 !important;
    box-shadow: none !important;
}

.pdf-rendering .source-row {
    background: #f8fafc !important;
    border: 1px solid #e2e8f0 !important;
    box-shadow: none !important;
    margin-bottom: 0.5rem !important;
    padding: 0.5rem !important;
}

.pdf-rendering .prn-usage-box {
    background: #f0fdfa !important;
    border: 1px dashed #0f766e !important;
}

.pdf-rendering .result-display {
    background: #f0fdf4 !important;
    border: 1px solid #bbf7d0 !important;
    box-shadow: none !important;
}

.pdf-rendering .result-display .result-value span:first-child {
    color: #16a34a !important;
}

.pdf-rendering .breakthrough-dose {
    background: #f8fafc !important;
    border: 1px solid #e2e8f0 !important;
}

.pdf-rendering .justification-box {
    border: 1px solid #e2e8f0 !important;
    background: #ffffff !important;
}